Our Research

Decoding apicomplexan biology through genomes and data systems

We integrate parasite genomics, bioinformatics infrastructure, and evolutionary and regulatory biology to understand how eukaryotic pathogens such as Toxoplasma gondii and Cryptosporidium evolve, regulate genes, and interact with hosts.

Apicomplexa Genome Evolution Data Integration Gene Regulation

Signature research themes

From global databases to parasite mitochondria, our work connects discovery science with usable infrastructure.

VEuPathDB logo

Data Integration & Infrastructure

Half of the lab builds the VEuPathDB ecosystem, creating ontology terms, web services, and automation that help researchers explore parasite, vector, and host datasets.

Regulatory motif visualization

Gene Regulation in Cryptosporidium

We study coordinated transcription during the first 72 hours of the in vitro life cycle and search for shared regulatory motifs across apicomplexans.

Diagnostic target discovery

Data Mining for Diagnostic Targets

Emerging genomic and functional data are mined for signatures that can improve diagnostics and point to new intervention strategies.

Mitochondrial genome of Toxoplasma gondii

Mitochondrial Genome of Toxoplasma

The Toxoplasma mitochondrial genome appears in many permutations, with thousands of fragments inserted into the nuclear genome, reshaping our view of organellar evolution.

How we connect the pipeline

From data generation to interpretation, we aim to make parasite biology discoverable and actionable.

Genome Data Generation

We partner with experimental teams to generate genomes, transcriptomes, and functional datasets that anchor downstream analysis.

Regulatory & Evolutionary Biology

Multi-omics integration reveals how parasite gene regulation, genome architecture, and evolutionary history shape pathogenicity.

Community Platforms

Our database development work ensures global researchers can visualize, query, and reuse parasite datasets with confidence.